memory and its disorders
Our laboratory at UCLA is studying learning, memory and its disorders.
Our field of study is Molecular and Cellular Cognition. The goal of this field is to derive explanations of cognitive processes that integrate molecular, cellular, circuit and behavioral mechanisms and to find treatments for cognitive disorders. We are part of the UCLA Integrative Center for Learning and Memory
- We are searching for the molecular, cellular and circuit processes that underlie the encoding, allocation, and storage of information in the brain.
- Insights into mechanisms of memory are being used to unravel the causes and develop treatments for cognitive deficits associated with aging, Intellectual disabilities, autism and schizophrenia. Recently, our studies in mice suggested that it is possible to reverse neurodevelopmental disorders, such as Intellectual disabilities associated with mutations in NF1, TSC and DISC1 in adults.
- Additionally, we hope our studies of the mechanisms underlying extraordinary cognitive function may lead to general treatments for cognitive disorders and to faster recovery after brain injury.
- Our laboratory is developing strategies to address the growing complexity of the literature. For example, we recently developed a free web application to derive maps of causal information from research papers (researchmaps.org) that could be used for integrating and planning experiments.
- New course, “Tools to integrate and plan experiments in neuroscience” taught by Alcino J Silva and Maryann E Martone; November 13, 2014 right before SFN in Washington DC!
- New PNAS paper on encoding and storing memory in retrosplinial cortex! (PDF)
- New Nature Reviews Neuroscience article on synaptic tagging during memory allocation (PDF)
- New Neuron paper on the need for Research Maps (PDF)
- New Book: Engineering the next revolution in neuroscience: the new science of experiment planning
- New Neuron paper on the importance of adult born neurons for psychiatric disorders (PDF)
- New Mol Psych paper on the interaction between TSC and gestational immune activation in autism (PDF)